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Trends Biochem Sci. 1998 May;23(5):174-8.

Role of the CCAAT-binding protein CBF/NF-Y in transcription.

Author information

1
Dept of Molecular Genetics, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA. sankar_maity@molgen.mdacc.tmc.edu

Abstract

The CCAAT motif is one of the common promoter elements present in the proximal promoter of numerous mammalian genes transcribed by RNA polymerase II. CBF (also called NF-Y and CP1) consists of three different subunits and interacts specifically with the CCAAT motif. In each CBF subunit, the segment needed for formation of the CBF-DNA complex is conserved from yeast to human and, interestingly, the conserved segment of two CBF subunits, CBF-A and CBF-C, are homologous to the histone-fold motif of eukaryotic histones and archaebacterial histone-like protein HMf-2. The histone fold motifs of CBF-A and CBF-C interact with each other to form a heterodimer that associates with CBF-B to form a heterotrimeric CBF molecule, which then binds to DNA.

PMID:
9612081
[Indexed for MEDLINE]

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