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Melanoma Res. 1998 Apr;8(2):156-60.

Multiple agminate Spitz naevi.

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1
Department of Dermatology, University Hospital Leiden, The Netherlands.

Abstract

We report two patients with multiple agminate Spitz naevi (MASM), a rare disorder. In case 1, a 16-year-old girl, the results of chromosomal investigation of fibroblasts from the affected area (translocation 45, X, t(4; 7) (p14; p22) in a mosaic pattern) suggest that early during embryogenesis a de novo reciprocal translocation has occurred between chromosomes 4 and 7. This resulted in the skin lesions as described on the right shoulder, arm and hand. The melanoma risk in MASM is also discussed.

PMID:
9610869
[Indexed for MEDLINE]
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