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Urology. 1998 May;51(5):693-6.

Clinical significance of tumor angiogenesis in patients with localized renal cell carcinoma.

Author information

1
Department of Urology, Bnai Zion Medical Center, Haifa, Israel.

Abstract

OBJECTIVES:

To determine the relationship between angiogenesis and various histopathologic features as well as clinical outcome in patients with localized renal cell carcinoma (RCC).

METHODS:

Microvessel density was quantified by using immunocytochemical staining of endothelial cells for factor VIII-related antigen of 36 specimens taken from patients with pathologic Stage pT1 or pT2 RCC. All patients underwent radical nephrectomy and were followed for a mean time of 97.3 months.

RESULTS:

No association was noted between microvessel count (MVC) and either cell type, architecture, or tumor size. Inverse correlation was noted between MVC and nuclear area (P = 0.006), nuclear elipticity (P = 0.016), nuclear roughness (P = 0.039), and histologic grade (P = 0.047). Patients having tumors with low MVC had significantly better survival rate compared with those with high MVC neoplasms (P = 0.0014, by Cox proportional hazards method).

CONCLUSIONS:

Despite lack of correlation with known predictors of survival, MVC provides independent prognostic information for patients with localized RCC.

PMID:
9610581
DOI:
10.1016/s0090-4295(98)00019-3
[Indexed for MEDLINE]

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