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Curr Opin Genet Dev. 1998 Apr;8(2):165-72.

Transcription of chromatin: these are complex times.

Author information

1
Regulatory Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA.

Abstract

Transcription of chromatin-packaged genes involves highly regulated changes in nucleosomal structure that control DNA accessibility. Two systems that facilitate these changes are ATP-dependent chromatin remodeling complexes and enzymatic complexes which control histone acetylation and deacetylation. Recent studies provide insight on the role of these remodeling machines and specific transcription factors in the expression of viral, inducible, and tissue-restricted genes.

PMID:
9610406
DOI:
10.1016/s0959-437x(98)80137-8
[Indexed for MEDLINE]

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