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Mol Cell Biochem. 1998 May;182(1-2):169-75.

TNF-alpha and insulin resistance: summary and future prospects.

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Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.


While the causes of obesity remain elusive, the relationship between obesity and insulin resistance is a well-established fact [1]. Insulin resistance is defined as a smaller than normal response to a certain dose of insulin, and contributes to several pathological problems of obese patients such as hyperlipidemia, arteriosclerosis and hypertension. Several pieces of evidence indicate that the cytokine tumor necrosis factor a (TNF-alpha) is an important player in the state of insulin resistance observed during obesity. In this review we will try to summarize what is known about the function of TNF-alpha in insulin resistance during obesity and how TNF-alpha interferes with insulin signaling.

[Indexed for MEDLINE]

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