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Mol Genet Metab. 1998 Mar;63(3):235-8.

Activation of membrane skeleton-bound phosphofructokinase in erythrocytes induced by serotonin.

Author information

1
Department of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.

Abstract

We show here that serotonin, both in vivo and in vitro, induced a marked activation of phosphofructokinase, the rate-limiting enzyme in glycolysis, in the membrane-skeleton fraction from erythrocytes. Concomitantly, the hormone induced a striking increase in lactate content, reflecting stimulation of glycolysis. The enzyme's activity in the cytosolic (soluble) fraction remained unchanged. These results suggest a defense mechanism in the erythrocytes against the damaging effects of serotonin, whose concentration in plasma increases in many diseases and is implicated as playing an important role in circulation disturbances.

PMID:
9608547
DOI:
10.1006/mgme.1997.2673
[Indexed for MEDLINE]

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