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J Infect Dis. 1998 Jun;177(6):1541-8.

The risk of disease progression is determined during the first year of human immunodeficiency virus type 1 infection.

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Institut National de la Transfusion Sanguine Laboratoire de Virologie, Hôpital Saint-Antoine, Paris, France.


A cohort of 103 human immunodeficiency virus type 1 (HIV-1)-infected persons with well-defined dates of seroconversion were studied to determine whether baseline plasma HIV RNA loads 6-12 months after seroconversion have prognostic value. Baseline plasma virus loads had predictive value for the disease-free survival rate and for the survival rate. The level of baseline HIV RNA also had a strong negative predictive value for the CD4+ T cell count during the fifth year of infection: A baseline load >5 log was predictive of a CD4+ T cell count <500/mm3 5 years after infection. Baseline HIV RNA load was a CD4+ T cell-independent predictor of progression to death. The major finding was that the disease outcome for HIV-1-infected persons is already determined during the first year of infection.

[Indexed for MEDLINE]

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