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Br J Surg. 1998 Apr;85(4):538-41.

Histamine in human breast cancer.

Author information

1
Department of Surgery, University of New South Wales, St George Hospital, Kogarah, Australia.

Abstract

BACKGROUND:

Histamine inhibits lymphocyte function in vitro at concentrations of greater than 10(-6) mol/l. The aim of this study was to determine whether histamine concentrations in breast cancers were sufficient to produce an immunological effect.

METHODS:

Tumour and adjacent normal breast content of histamine was measured using a radioenzymatic assay in 29 patients having surgery for breast cancer.

RESULTS:

The median content of histamine in breast cancer tissue was 5.4 (range 0.9-27.3) microg/g (median concentration 4.5 x 10(-5) mol/l), and was significantly greater than that in adjacent breast tissue (P = 0.007).

CONCLUSION:

The concentration of histamine in breast cancer was sufficient to inhibit lymphocyte function and could be locally immunosuppressive.

[Indexed for MEDLINE]

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