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Am J Hypertens. 1998 Apr;11(4 Pt 1):471-7.

Replacing short-acting nifedipine with alternative medications at a large health maintenance organization.

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  • 1Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle 98101, USA.


In response to recent evidence about the safety of calcium channel blockers, Group Health Cooperative of Puget Sound (GHC), a large health maintenance organization, implemented a plan in April 1996 to reevaluate the medications of 1349 patients who were taking short-acting nifedipine. Following the intervention, 79.8% of patients taking short-acting nifedipine discontinued use, and 45.6% switched to once-daily felodipine. By presenting physicians and patients with recent evidence about the safety of short-acting nifedipine, a large health maintenance organization was able to motivate broad-scale changes to safer alternative drug therapies.

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