In the clinic 307 patients with suppurative lesions were observed, in 183 of them (the main group) staphylococcic anatoxin was administered with prophylactic and therapeutic purposes, 124 patients (the control group) were treated with antibiotics, including 231 patients with acute appendicitis, 23--with osteomyelitis, 48--with mastitis and 5 patients with various purulent complications of staphylococcic etiology. Among 231 patients with acute appendicitis 125 comprised the main group who were injected staphylococcic anatoxin, and 106--the control group. In the latter the incidence of the operative wound suppuration was observed thrice as frequently.