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Curr Opin Immunol. 1998 Apr;10(2):226-32.

T lymphocyte differentiation in the periphery.

Author information

1
Howard Hughes Medical Institute, Washington University School of Medicine, Pathology Department, St Louis, MO 63110, USA. murphy@immunology.wustl.edu

Abstract

The development of immune responses is significantly influenced by emerging patterns of cytokine expression in activated CD4+ T cells. Recent efforts have clarified both cellular and molecular mechanisms, and within the past year include significant observations on potential sources of IL-4 leading to Th2 development against certain pathogens, and insights into early responses and genetic susceptibility to experimental murine Leishmaniasis and transcriptional regulation of the IL-4 locus. Advances in Th1 development have included greater understanding of IL-12 receptors in Th1 development, data regarding IFN-gamma gene expression and clarification of the action of the new cytokine IL-18.

PMID:
9602313
DOI:
10.1016/s0952-7915(98)80253-7
[Indexed for MEDLINE]

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