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Curr Opin Immunol. 1998 Apr;10(2):137-44.

Reading within the lines: naturally processed peptides displayed by MHC class I molecules.

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Department of Molecular and Cell Biology, University of California, Berkeley 94720-3200, USA.


A typical mammalian cell contains tens of thousands of different gene products. Snippets of this genetic information are displayed on the cell surface by MHC class I molecules as short peptides for immune surveillance by CD8+ T lymphocytes. Genetic and biochemical analysis of these peptides is revealing novel sources and mechanisms by which these peptide/MHC class I complexes arise.

[Indexed for MEDLINE]

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