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Brain Res Mol Brain Res. 1998 May;56(1-2):281-3.

mu-Opioid receptor-knockout mice: the role of mu-opioid receptor in gastrointestinal transit.

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Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.


The role of mu-opioid receptor in gastrointestinal transit was investigated using mu-opioid receptor knockout mice (MOR-KO). Our result establishes unequivocally that inhibition of GI transit by morphine is a mu-opioid receptor mediated function. In addition, we show that neither delta nor kappa receptor agonist given supraspinally or peripherally are able to inhibit GI transit in MOR-KO animals. It was interesting to observe that basal GI motility was lower in MOR-KO (-/-) compared to heterozygous (+/-) and wild type (+/+) animals.

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