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Brain Res Dev Brain Res. 1998 Apr 17;107(1):165-7.

Morphological consequences of altered calcium-dependent transmembrane signaling on the development of cultured cerebellar Purkinje neurons.

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Dept. of Physiology, University of Arizona, Tucson 85724-5051, USA.


Morphometric analyses of cultured rat Purkinje neurons, visualized with anti-calbindin, demonstrated that elevated KCl (10 mM) significantly increased dendritic outgrowth and branching. The response was blocked by NiCl2 (50 microM; R-type Ca2+ channel antagonist). Cells grown in low external Ca2+ (100 nM) showed no loss of responsiveness to elevated potassium. However, thapsigargin (1 microM; Ca(2+)-ATPase blocker) inhibited dendrite outgrowth, suggesting that intracellular calcium stores may be important in governing development.

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