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JAMA. 1998 May 13;279(18):1474-6.

Influence of a child's sex on medulloblastoma outcome.

Author information

1
Department of Radiation Oncology, University of California, San Francisco, USA. mweil@brown.uhcolorado.edu

Abstract

CONTEXT:

Aggressive treatment of medulloblastoma, the most common pediatric brain tumor, has not improved survival. Identifying better prognostic indicators may warrant less morbid therapy.

OBJECTIVE:

To investigate the role of sex on outcome of medulloblastoma.

DESIGN:

Retrospective study of significant factors for survival with a median follow-up of 82 months.

SETTING:

University medical center.

PATIENTS:

A total of 109 consecutive, pediatric patients treated for primary medulloblastoma from 1970 to 1995 with surgery and postoperative radiotherapy and, after 1979, chemotherapy.

MAIN OUTCOME MEASURES:

Factors independently associated with survival.

RESULTS:

The final multivariate model predicting improved survival included sex (hazard ratio, 0.52; 95% confidence interval [CI], 0.29-0.92; P=.03; favoring female), metastases at presentation (hazard ratio, 2.01; 95% CI, 1.14-3.52; P=.02), and extent of surgical resection (hazard ratio, 0.60; 95% CI, 0.34-1.04; P=.07; favoring greater resection). The overall, 5-year freedom from progression was 40% and survival was 49%. Radiotherapy dose (P=.72), and chemotherapy (P=.90) did not significantly affect a disease outcome.

CONCLUSIONS:

The sex of the child was an important predictor for survival of medulloblastoma; girls had a much better outcome. The difference in survival between sexes should be evaluated in prospective, clinical trials.

PMID:
9600483
[Indexed for MEDLINE]
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