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Biochem Biophys Res Commun. 1998 May 8;246(1):55-8.

The role of p38 MAP kinase in TGF-beta1-induced signal transduction in human neutrophils.

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Department of Pathology, University of Connecticut Health Center, Farmington 06030, USA.


Transforming growth factor-beta 1 (TGF-beta 1) is the strongest chemoattractant yet described for human neutrophils. It activates neither phospholipase C nor phospholipase D. It does not induce rises in intracellular calcium, degranulation, or superoxide production. The signaling pathways utilized by TGF-beta 1 are largely unknown. This report demonstrates that TGF-beta 1 activates p38 MAP kinase. The kinase inhibitor SB203580 blocks the chemotactic responses as well as actin polymerization induced by TGF-beta 1. Potential cellular targets of the p38 MAP kinase pathway which could mediate these function are discussed.

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