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Neurology. 1998 May;50(5):1458-61.

A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease.

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Department of Environmental Health, University of Washington, Seattle 98195-7234, USA.


In a population-based case-control study, we found a reversal of the association of cigarette smoking with Parkinson's disease (PD) in relation to the monoamine oxidase B intron 13 genetic polymorphism. A reduced PD risk related to pack-years of smoking was detected for persons with the G allele, whereas an opposite effect was found among persons with the A allele. These results indicate an unexplained interaction between cigarette smoking and this genetic polymorphism.

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[Indexed for MEDLINE]

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