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J Dent. 1998 Mar;26(3):267-71.

Antibacterial activity of dentine primer containing MDPB after curing.

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  • 1Department of Operative Dentistry, Osaka, University Faculty of Dentistry, Japan.



A monomer methacryloyloxydodecylpyridinium bromide (MDPB) has antibacterial activity before polymerization. Furthermore, the antibacterial agent is immobilized by the polymerization of MDPB and the resin-based material incorporating MDPB is able to show an antibacterial effect even after being cured. The purpose of this study was to investigate the antibacterial effect of a dentine primer containing MDPB after curing.


The inhibitory effect of a cured MDPB-containing primer on the growth of Streptococcus mutans, Actinomyces viscosus and Lactobacillus casei was determined by the agar-disc method. The bactericidal activity of cured primer during a 1-h contact period was assessed using S. mutans, and the elution of unpolymerized MDPB was measured with high performance liquid chromatography.


Cured MDPB-containing primer showed an inhibitory effect on the growth of all species which were in contact with the specimen surface, and displayed a little bactericidal effect on S. mutans without releasing any unpolymerized antibacterial components.


Incorporation of antibacterial monomer MDPB into dentine primer is beneficial for providing antibacterial activity after curing.

[PubMed - indexed for MEDLINE]
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