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Brain Res. 1998 Apr 27;791(1-2):63-6.

Cerebrovascular muscle atrophy is a feature of Alzheimer's disease.

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1
Institute of Pathology, 2085 Adelbert Road, Case Western Reserve University, Cleveland, OH 44106, USA. gxp7@po.cwru.edu

Abstract

We examined vascular amyloid-beta deposition and other abnormalities in the posterior cerebral artery of consecutive cases of Alzheimer's disease (AD) compared to controls. Smooth muscle atrophy was a consistent feature in the cases of AD examined (p<0.01) and was surprisingly independent of adjacent amyloid-beta deposition. These findings suggest that vascular abnormalities are a consistent feature in AD and may be an important contributor to the pathogenesis and complications of AD.

PMID:
9593825
[Indexed for MEDLINE]
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