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Tumour Biol. 1998;19(3):205-12.

Analysis of the T cell receptor variability of tumor-infiltrating lymphocytes in colorectal carcinomas.

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Abteilung f├╝r Allgemeinchirurgie mit Poliklinik, Chirurgische Universit├Ątsklinik, Freiburg, Deutschland.


While there is good clinical and experimental evidence for immunological tumor control in some tumors--malignant melanomas, for instance--the immunogenicity of colorectal carcinoma (CRC) still remains unsettled. We examined surgical specimens from 4 CRC patients for T cell clones among tumor-infiltrating lymphocytes (TIL). The growth of specific lymphocyte clones in a tumor indicates an immunological response in vivo. We used a T cell receptor V beta family-specific semiquantitative PCR with additional sequencing to examine TIL for clonal expansion. In CRC, specific T cell clones could not be demonstrated. However, we observed a predominance of V beta 9 in 3 of 4 tumors.

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