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Genes Dev. 1998 May 15;12(10):1409-14.

Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis.

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  • 1Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115,


The U2 snRNP component SAP 155 contacts pre-mRNA on both sides of the branch site early in spliceosome assembly and is therefore positioned near or at the spliceosome catalytic center. We have isolated a cDNA encoding human SAP 155 and identified its highly related Saccharomyces cerevisiae homolog (50% identity). The carboxy-terminal two-thirds of SAP 155 shows the highest conservation and is remarkably similar to the regulatory subunit A of the phosphatase PP2A. Significantly, SAP 155 is phosphorylated concomitant with or just after catalytic step one, making this the first example of a protein modification tightly regulated with splicing catalysis.

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