Format

Send to

Choose Destination
See comment in PubMed Commons below
Ann Neurol. 1998 May;43(5):673-6.

Neuropathology of preclinical and clinical late-onset Alzheimer's disease.

Author information

1
Alzheimer's Disease Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2196, USA.

Abstract

We report on the neuropathological examinations of a 74-year-old woman with Alzheimer's disease (AD) and of her 47-year-old nondemented daughter. The brain of the mother showed fully developed pathological changes of AD. By contrast, the brain of the daughter revealed only perineuronal deposition of diffuse amyloid in cerebral cortex and striking abnormalities of the endosomal-lysosomal system, without neurofibrillary, glial, or microglial changes. These observations suggest that amyloid deposition and endosomal-lysosomal changes are early events in late-onset AD and that they may precede the onset of dementia by several decades.

PMID:
9585365
DOI:
10.1002/ana.410430519
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center