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Trends Biochem Sci. 1998 Apr;23(4):138-43.

The ins and outs of a molecular chaperone machine.

Author information

1
Département de Biochimie Médicale, Université de Genève, Switzerland. Alexandra.Richardson@medicine.unige.ch

Abstract

Genetic and biochemical work has highlighted the biological importance of the GroEL/GroES (Hsp60/Hsp10; cpn60/cpn10) chaperone machine in protein folding. GroEL's donut-shaped structure has attracted the attention of structural biologists because of its elegance as well as the secrets (substrates) it can hide. The recent determination of the GroES and GroEL/GroES structures provides a glimpse of their plasticity, revealing dramatic conformational changes that point to an elaborate mechanism, coupling ATP hydrolysis to substrate release by GroEL.

PMID:
9584617
DOI:
10.1016/s0968-0004(98)01193-1
[Indexed for MEDLINE]

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