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Trends Microbiol. 1998 Mar;6(3):107-12.

Mechanisms of latency in Mycobacterium tuberculosis.

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Dept of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, MD 21205-2179, USA.


Mycobacterium tuberculosis can persist within the human host for years without causing disease, in a syndrome known as latent tuberculosis (TB). As one-third of the world population has latent TB, placing them at risk for active TB, the mechanisms by which M. tuberculosis establishes a latent metabolic state, eludes immune surveillance and responds to triggers that stimulate reactivation are a high priority for the future control of TB.

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