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Nature. 1998 Apr 30;392(6679):885-8.

Allosteric effects of DNA on transcriptional regulators.

Author information

1
Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143-0450, USA. lefstin@stanford.edu

Abstract

Selective gene transcription is mediated in part by regulatory proteins that bind to DNA response elements. These regulatory proteins receive global information from signal-transduction events. But transcriptional regulators may also be modified in an allosteric manner by response elements themselves to generate the pattern of regulation that is appropriate to an individual gene.

PMID:
9582068
DOI:
10.1038/31860
[Indexed for MEDLINE]

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