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J Ethnopharmacol. 1998 Mar;60(2):173-8.

Effect of ashwagandha on lipid peroxidation in stress-induced animals.

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Hindustan Antibiotics Limited, Department of Pharmacology and Toxicology, Research Centre, Pimpri, Pune, India.


The aqueous suspension of root extract of an Indian drug ashwagandha (Withania somnifera L. (Solanaceae)) was evaluated for its effect on lipid peroxidation (LPO) in stress-induced animals. Elevation of LPO was observed in rabbits and mice after intravenous administration of 0.2 microg/kg of lipopolysaccharide (LPS: from Klebsiella pneumoniae) and 100 microg/kg of peptidoglycan (PGN: from Staphylococcus aureus), respectively. The peak was reached immediately after PGN and 2-6 h after LPS administration. Simultaneous oral administration of ashwagandha (100 mg/kg) prevented the rise in LPO in rabbits and mice.

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