Send to

Choose Destination
Prev Med. 1998 Mar-Apr;27(2):208-11.

Quality of early care and buffering of neuroendocrine stress reactions: potential effects on the developing human brain.

Author information

Institute of Child Development, University of Minnesota, Minneapolis 55455, USA.


Brain development is affected by stress early in development. Activity of the hypothalamic-pituitary-adrenocortical (HPA) axis plays a role in mediating the effects of adversity on the developing brain. The impact of glucocorticoids on brain development has been studied in animal models. The literature linking activity of the HPA axis to memory, attention, and emotion in human children is briefly reviewed. Evidence for decreased reactivity of the HPA system developing over the first year of life is presented. Finally, the role of sensitive and responsive caregiving in buffering reactivity of the HPA system to potentially stressful events is described. It is argued that these data provide yet more support for the importance of fostering safe, secure care for children early in their development.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center