Abstract
The antimicrobial susceptibility of 1078 isolates of Haemophilus influenzae, 348 Streptococcus pneumoniae and 258 Moraxella catarrhalis was determined. Overall 15.1% of H. influenzae produced beta-lactamase; 98.8% were susceptible to co-amoxiclav, 85.8% to cefaclor, 96% to clarithromycin and 100% to ciprofloxacin. The majority (94.2%) of M. catarrhalis produced beta-lactamase. The overall prevalence of low-level penicillin resistance (MIC = 0.12-1 mg/L) amongst isolates of S. pneumoniae was 3.4% and that of high-level resistance (MIC > or = 2 mg/L) was 3.7%. Most (96.3%) of the isolates of S. pneumoniae were susceptible to amoxycillin (MIC < or = 0.5 mg/L), 96% to cefaclor (MIC < or = 8 mg/L), 90.7% to clarithromycin (MIC < or = 0.25 mg/L) and 89% to ciprofloxacin (MIC < or = 1 mg/L).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amoxicillin-Potassium Clavulanate Combination / administration & dosage
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Amoxicillin-Potassium Clavulanate Combination / pharmacology
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Ampicillin / administration & dosage
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Ampicillin / pharmacology
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Ampicillin Resistance
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / pharmacology*
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Bacteria / drug effects*
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Bacteria / isolation & purification
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Bacterial Infections / microbiology
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Cefaclor / administration & dosage
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Cefaclor / pharmacology
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Cephalosporins / administration & dosage
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Cephalosporins / pharmacology
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Ciprofloxacin / administration & dosage
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Ciprofloxacin / pharmacology
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Clarithromycin / administration & dosage
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Clarithromycin / pharmacology
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Common Cold / microbiology*
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Community-Acquired Infections / epidemiology
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Community-Acquired Infections / microbiology
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Dose-Response Relationship, Drug
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Haemophilus influenzae / drug effects
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Haemophilus influenzae / enzymology
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Haemophilus influenzae / isolation & purification
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Humans
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Microbial Sensitivity Tests
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Moraxella catarrhalis / drug effects
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Moraxella catarrhalis / isolation & purification
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Multicenter Studies as Topic
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Penicillins / administration & dosage
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Penicillins / pharmacology
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Respiratory System / microbiology
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Respiratory Tract Infections / epidemiology
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Respiratory Tract Infections / microbiology*
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Streptococcus pneumoniae / drug effects
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Streptococcus pneumoniae / isolation & purification
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United Kingdom / epidemiology
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beta-Lactam Resistance
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beta-Lactamases
Substances
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Anti-Bacterial Agents
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Cephalosporins
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Penicillins
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Ciprofloxacin
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Cefaclor
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Amoxicillin-Potassium Clavulanate Combination
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Ampicillin
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beta-Lactamases
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Clarithromycin