Antimicrobial susceptibility of community-acquired lower respiratory tract bacterial pathogens isolated in the UK during the 1995-1996 cold season

J Antimicrob Chemother. 1998 Mar;41(3):411-5. doi: 10.1093/jac/41.3.411.

Abstract

The antimicrobial susceptibility of 1078 isolates of Haemophilus influenzae, 348 Streptococcus pneumoniae and 258 Moraxella catarrhalis was determined. Overall 15.1% of H. influenzae produced beta-lactamase; 98.8% were susceptible to co-amoxiclav, 85.8% to cefaclor, 96% to clarithromycin and 100% to ciprofloxacin. The majority (94.2%) of M. catarrhalis produced beta-lactamase. The overall prevalence of low-level penicillin resistance (MIC = 0.12-1 mg/L) amongst isolates of S. pneumoniae was 3.4% and that of high-level resistance (MIC > or = 2 mg/L) was 3.7%. Most (96.3%) of the isolates of S. pneumoniae were susceptible to amoxycillin (MIC < or = 0.5 mg/L), 96% to cefaclor (MIC < or = 8 mg/L), 90.7% to clarithromycin (MIC < or = 0.25 mg/L) and 89% to ciprofloxacin (MIC < or = 1 mg/L).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amoxicillin-Potassium Clavulanate Combination / administration & dosage
  • Amoxicillin-Potassium Clavulanate Combination / pharmacology
  • Ampicillin / administration & dosage
  • Ampicillin / pharmacology
  • Ampicillin Resistance
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / pharmacology*
  • Bacteria / drug effects*
  • Bacteria / isolation & purification
  • Bacterial Infections / microbiology
  • Cefaclor / administration & dosage
  • Cefaclor / pharmacology
  • Cephalosporins / administration & dosage
  • Cephalosporins / pharmacology
  • Ciprofloxacin / administration & dosage
  • Ciprofloxacin / pharmacology
  • Clarithromycin / administration & dosage
  • Clarithromycin / pharmacology
  • Common Cold / microbiology*
  • Community-Acquired Infections / epidemiology
  • Community-Acquired Infections / microbiology
  • Dose-Response Relationship, Drug
  • Haemophilus influenzae / drug effects
  • Haemophilus influenzae / enzymology
  • Haemophilus influenzae / isolation & purification
  • Humans
  • Microbial Sensitivity Tests
  • Moraxella catarrhalis / drug effects
  • Moraxella catarrhalis / isolation & purification
  • Multicenter Studies as Topic
  • Penicillins / administration & dosage
  • Penicillins / pharmacology
  • Respiratory System / microbiology
  • Respiratory Tract Infections / epidemiology
  • Respiratory Tract Infections / microbiology*
  • Streptococcus pneumoniae / drug effects
  • Streptococcus pneumoniae / isolation & purification
  • United Kingdom / epidemiology
  • beta-Lactam Resistance
  • beta-Lactamases

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • Penicillins
  • Ciprofloxacin
  • Cefaclor
  • Amoxicillin-Potassium Clavulanate Combination
  • Ampicillin
  • beta-Lactamases
  • Clarithromycin