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Epilepsia. 1998 Apr;39(4):438-41.

Complex partial status epilepticus in late-onset MELAS.

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National Hospital for Neurology and Neurosurgery, London, England, UK.


A patient with recurrent episodes of complex partial status epilepticus and a distinctive pattern of periodic lateralized epileptiform discharges (PLEDs) is presented. The patient was subsequently shown to have a mitochondrial disorder of the MELAS type, a hitherto unreported association. The case illustrates that CPSE should be added to the list of possible causes of acute neurological deterioration in MELAS patients.

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