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Immunol Today. 1998 Apr;19(4):157-63.

How the MHC selects Th1/Th2 immunity.

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Dept of Microbiology, University of Kansas, Lawrence 66045, USA.


While the effects of cytokines on T helper 1 (Th1)/Th2 differentiation are well documented, it is less clear why a dichotomy of effector cytokine production would initiate from antigen-specific lymphocytes. Nevertheless, in defined experimental systems, the interaction between T-cell receptor (TCR), peptide and major histocompatibility complex (MHC) can determine Th1/Th2 dominance. Here, Joseph Murray discusses how TCR affinity and ligand density might interface with innate forces in the selection of CD4+ T-cell functions.

[Indexed for MEDLINE]

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