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Immunol Today. 1998 Apr;19(4):153-7.

Regulation of KIR expression in human T cells: a safety mechanism that may impair protective T-cell responses.

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Dipartimento di Oncologia Clinica e Sperimentale, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.


Killer-cell inhibitory Receptors (KIRs) are a new family of major histocompatibility complex (MHC) class I-specific receptors. KIRs allow natural killer cells to identify and lyse self cells that do not express sufficient amounts of MHC class I molecules. Here, Maria Cristina Mingari and colleagues view the expression of KIRs by cytolytic T lymphocytes and their regulation by certain cytokines as a double-edged sword.

[Indexed for MEDLINE]

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