Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Neurobiol. 1998 Feb;8(1):139-48.

LTP and activity-dependent synaptogenesis: the more alike they are, the more different they become.

Author information

1
Department of Molecular Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520-8103, USA. Martha.Constantine-Paton@Yale.edu

Abstract

Recent data suggest that long-term potentiation and activity-dependent synaptogenesis share the same mechanism at the initiation stage during which NMDA receptor activity is necessary to increase the postsynaptic response via AMPA receptor currents. However, several fundamental differences between the environments of young and mature synapses and the neurons that support them suggest that the same cellular mechanism is facilitated by very different parameters in the young versus the mature brain.

PMID:
9568401
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center