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Anticancer Res. 1998 Jan-Feb;18(1A):471-3.

beta-Sitosterol inhibits growth of HT-29 human colon cancer cells by activating the sphingomyelin cycle.

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Department of Physical Therapy, Exercise and Nutrition Sciences, SUNY/Buffalo, NY 14214, USA.

Erratum in

  • Anticancer Res 1998 Mar-Apr;18(2A):1227.


The present study examined the SM cycle as a mechanism to explain the inhibitory effect of SIT on HT-29 cell growth. SIT was the main phytosterol in the diet. Supplementation of SIT at 16 microM for 5 days in the media inhibited growth by 55% as compared to cholesterol. SIT supplementation had no effect on sphingosine production. Ceramide production increased 45% with SIT supplementation as compared to cholesterol. Sterol supplementation had no effect on phospholipase C, a key enzyme in the PKC pathway. We concluded that the activation of the SM cycle may play a role in growth inhibition of HT-29 cells by SIT.

[Indexed for MEDLINE]

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