Format

Send to

Choose Destination
See comment in PubMed Commons below
Chem Biol Interact. 1998 Mar 12;110(1-2):1-5.

Indole-3-carbinol: anticarcinogen or tumor promoter in brassica vegetables?

Author information

1
Department of Environmental Biochemistry, University of Hawaii, Honolulu 96822, USA. dashwood@hawaii.edu

Abstract

Indole-3-carbinol (I3C) is one of several compounds in brassica vegetables that demonstrate anticarcinogenic effects in experimental animals. A review of Medline and CancerLit databases indicated that interest in I3C, as a cancer chemopreventive agent, has increased significantly in the past 5-10 years. Whereas most studies report inhibitory or protective effects of I3C in vivo, a few provide clear evidence for promotion or enhancement of carcinogenesis, depending upon the initiator, exposure protocol and species. In the absence of detailed information on the inhibitory and in particular, promotional mechanisms, it would seem advisable to proceed with caution before including I3C in extensive human clinical trials.

PMID:
9566721
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center