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Nutr Rev. 1998 Feb;56(2 Pt 2):s47-53; discussion s54-75.

The implications of genetic diversity for nutrient requirements: the case of folate.


"The existence of chemical individuality follows of necessity from that of chemical specificity, but we should expect the differences between individuals to be still more subtle and difficult of detection. Indications of their existence are seen, even in man,... in the quantitative differences in those portions of the end products of metabolism which are endogenous and are not affected by diet.... Even those idiosyncracies with regard to... articles of food which are summed up in the proverbial saying that what is one's man meat is another man's poison, presumably have a chemical basis."

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