Send to

Choose Destination
See comment in PubMed Commons below
FEBS Lett. 1998 Apr 3;425(3):485-9.

In vitro interaction of the carboxy-terminal domain of lamin A with actin.

Author information

  • 1Centre de Recherche du Centre Hospitalier de l'Université de Montréal and Institut du Cancer de Montréal, Qué., Canada.


The nuclear lamina formed by lamins is localized between the inner nuclear membrane and chromatin. Lamins are thought to be implicated in the higher order chromatin structure. Interactions of lamins with chromatin have been described but the molecular components directly involved in these interactions remain to be identified. Using a GST-C-terminal domain of lamin A fusion protein to probe cellular extracts for interacting proteins, we have found that this domain of lamin A binds to nuclear actin. This result suggests that an actin-based molecular motor linked to the lamina could be involved in the movement of chromatin domains.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center