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Curr Opin Cell Biol. 1998 Apr;10(2):262-7.

Mechanisms and consequences of activation of protein kinase B/Akt.

Author information

1
Imperial Cancer Research Fund, London, UK. downward@icrf.icnet.uk

Abstract

Protein kinase B (PKB)/Akt is a growth-factor-regulated serine/threonine kinase which contains a pleckstrin homology domain. Binding of phosphoinositide 3-OH kinase products to the pleckstrin homology domain results in translocation of PKB/Akt to the plasma membrane where it is activated by phosphorylation by upstream kinases including the phosphoinoside-dependent kinase 1 (PDK1). Activated PKB/Akt provides a survival signal that protects cells from apoptosis induced by various stresses, and also mediates a number of metabolic effects of insulin.

PMID:
9561851
[Indexed for MEDLINE]

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