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Curr Opin Cell Biol. 1998 Apr;10(2):254-61.

The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate.

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Boston Biomedical Research Institute, MA 02114, USA.


Phosphatidylinositol 4,5-bisphosphate (PtdIns 4,5-P2) is a membrane phospholipid found in all eukaryotic cells which regulates many important cellular processes, including organization of the cytoskeleton, vesicular trafficking and platelet activation. PtdIns 4,5-P2 can either act as a substrate for lipid kinases and phosphatases, or directly interact with proteins. Recent work has focused on the characterization of the enzymes that regulate PtdIns 4,5-P2 levels in the cell. The discovery of proteins whose activities are modified by interaction with PtdIns 4,5-P2 has helped to redefine the role of this lipid in cell biology.

[Indexed for MEDLINE]

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