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Curr Opin Cell Biol. 1998 Apr;10(2):205-19.

Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development.

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1
Department of Cell Biology, University of Massachusetts Medical School, Worcester 01605, USA.

Abstract

The c-Jun amino-terminal kinase (JNK) group of MAP kinases has been identified in mammals and insects. JNK is activated by exposure of cells to cytokines or environmental stress, indicating that this signaling pathway may contribute to inflammatory responses. Genetic and biochemical studies demonstrate that this signaling pathway also regulates cellular proliferation, apoptosis, and tissue morphogenesis. A functional role for JNK is therefore established in both the cellular response to stress and in many normal physiological processes.

PMID:
9561845
[Indexed for MEDLINE]
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