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J Eukaryot Microbiol. 1998 Mar-Apr;45(2):24S-27S.

The effects of Entamoeba histolytica lysates on human colonic mucins.

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Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, UK.


Detergent lysates of Entamoeba histolytica trophozoites contained high levels of beta-N acetyl-D-glucosaminidase, beta-N acetyl-D-galactosaminidase and alpha-D-galactosidase activity, and lower but significant levels of five other glycosidases. Although these activities should have been capable of largely degrading the oligosaccharide side-chains of human colonic mucin, in fact only about one third of high MW mucin was degraded in 72 h and trypsin alone produced a similar effect. There was no evidence that these glycosidases were excreted and we conclude that they are unlikely to represent significant virulence factors for E. histolytica.

[Indexed for MEDLINE]

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