Format

Send to

Choose Destination
Antimicrob Agents Chemother. 1998 Apr;42(4):927-9.

Effect of grapefruit juice on clarithromycin pharmacokinetics.

Author information

1
Department of Pharmacy Services, Bassett Healthcare, Cooperstown, New York 13326-1394, USA.

Abstract

To investigate whether grapefruit juice inhibits the metabolism of clarithromycin, 12 healthy subjects were given water or grapefruit juice before and after a clarithromycin dose of 500 mg in a randomized crossover study. Administration of grapefruit juice increased the time to peak concentration of both clarithromycin (82 +/- 35 versus 148 +/- 83 min; P = 0.02) and 14-hydroxyclarithromycin (84 +/- 38 min versus 173 +/- 85; P = 0.01) but did not affect other pharmacokinetic parameters.

PMID:
9559810
PMCID:
PMC105569
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center