Format

Send to

Choose Destination
Crit Care Med. 1998 Apr;26(4):797-801.

Functional and ultrastructural evidence of myocardial stunning after acute carbon monoxide poisoning.

Author information

1
Department of Anesthesia and Intensive Care, Faculty of Medicine, University of Rome La Sapienza, Italy.

Abstract

OBJECTIVE:

To study human myocardial ultrastructural changes after carbon monoxide (CO) poisoning inducing reversible cardiac failure.

DESIGN:

CASE REPORT:

clinical, functional and morphologic findings.

SETTINGS:

Public university-affiliated hospital and electron microscopy laboratory.

PATIENT:

A 25-yr-old woman with functional evidence of cardiac failure after acute CO poisoning.

INTERVENTIONS:

Hyperbaric and intensive care treatment over 10 days. Scintigraphic and cardiac angiography with endomyocardial biopsy.

MEASUREMENTS AND MAIN RESULTS:

Scintigraphy with 99mTc hexakis 2-methoxy-2-isobutyl isonitrile (sestaMIBI) showed an uptake defect in the left anterior descending artery territory. The cardiac angiography demonstrated a slight hypokinesis of the superior two thirds of the anterior wall and of the septal region with completely normal coronary angiograms. Electron microscopy of left ventricular biopsies showed slight ultrastructural changes in the myocytes. In addition, large glycogen deposits were mostly associated with swollen mitochondria. The patient was discharged in good clinical condition on day 10.

CONCLUSIONS:

Presence of glycogen deposits associated with abnormal mitochondria may be signs of the incapability of myocardial cells in utilizing energy substrata. In the presence of normal myocardial perfusion, our findings are consistent with the presence of a stunned myocardium-like syndrome. Early recognition and treatment of this clinical syndrome allow the prevention of myocardial infarction.

PMID:
9559621
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center