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Curr Opin Lipidol. 1998 Apr;9(2):113-8.

Two 7 alpha-hydroxylase enzymes in bile acid biosynthesis.

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  • 1Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235-9046, USA.


The addition of a 7-hydroxyl group is an early and often rate-limiting step in the synthesis of bile acids. This reaction is catalysed by two cytochrome P450 enzymes known as cholesterol 7 alpha-hydroxylase and oxysterol 7 alpha-hydroxylase. cDNAs encoding these proteins have been isolated and used to define two evolutionarily conserved pathways that produce 7 alpha-hydroxylated bile acids.

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