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Can Fam Physician. 1998 Mar;44:495-8.

Is topical tretinoin safe during the first trimester?

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1
Hospital for Sick Children, Toronto.

Abstract

QUESTIONOne of my patients conceived while using a topical tretinoin preparation for acne. I know this drug is related to Accutane, which is teratogenic. How should I advise her?ANSWERAvailable evidence suggests that topical tretinoin does not increase teratogenic risk in humans.

PMID:
9559187
PMCID:
PMC2277705
[Indexed for MEDLINE]
Free PMC Article
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