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Autoimmunity. 1997;26(1):33-42.

Heat shock proteins and arthritis--new readers start here.

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Department of Medicine, University of Cambridge.


The possible roles of heat shock proteins in the pathogenesis of inflammatory arthritis have been discussed for a number of years, and investigated intensively in both animal models and human disease. This review surveys evidence which has pointed, on the one hand, to hsp as targets of a pathogenic immune response, and on the other, to an immunoregulatory role for T cell recognition of self hsp. The extent to which findings in experimental animals have led to further insights applicable to human disease is also emphasised.

[Indexed for MEDLINE]

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