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Science. 1998 Apr 24;280(5363):582-5.

Dependence of germinal center B cells on expression of CD21/CD35 for survival.

Author information

1
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Affinity-driven selection of B lymphocytes within germinal centers is critical for the development of high-affinity memory cells and host protection. To investigate the role of the CD21/CD35 coreceptor in B cell competition for follicular retention and survival within the germinal center, either Cr2+ or Cr2null lysozyme-specific transgenic B cells were adoptively transferred into normal mice immunized with duck (DEL) or turkey (TEL) lysozyme, which bind with different affinities. In mice injected with high-affinity turkey lysozyme, Cr2null B cells responded by follicular retention; however, they could not survive within germinal centers. This suggests that CD21 provides a signal independent of antigen that is required for survival of B cells in the germinal center.

PMID:
9554848
DOI:
10.1126/science.280.5363.582
[Indexed for MEDLINE]
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