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Prog Cell Cycle Res. 1996;2:217-28.

Role of Ca++/calmodulin binding proteins in Aspergillus nidulans cell cycle regulation.

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Department of Pharmacology, Duke University Medical Center, Durham NC 27710, USA.


The goal of this review is to summarise the current knowledge concerning the targets of Ca++/calmodulin that are essential for cell cycle progression in lower eukaryotes. Emphasis is placed on Aspergillus nidulans since this is the only organism to date shown to posses essential Ca++ dependent calmodulin activated enzymes. Two such enzymes are the calmodulin activated protein phosphatase, calcineurin and the calmodulin dependent protein kinase. These proteins, each the product of a unique gene, are required for progression of quiescent spores into the proliferative cycle and also for execution of the nuclear division cycle in exponentially growing germlings.

[Indexed for MEDLINE]

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