Send to

Choose Destination
Prog Cell Cycle Res. 1995;1:53-71.

Mechanism of action of rapamycin: new insights into the regulation of G1-phase progression in eukaryotic cells.

Author information

Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA.


The immunosuppressant drug, rapamycin (RAP), is a potent inhibitor of IL-2-dependent T-cell proliferation. The antiproliferative effect of RAP is mediated through the formation of an active complex with its cytosolic receptor protein, FKBP12. The molecular target of the FKBP12.RAP complex is a putative lipid kinase termed the mammalian Target Of Rapamycin (mTOR). This review will discuss recent findings suggesting that mTOR is a novel regulator of G1- to S-phase progression in eukaryotic cells.

[Indexed for MEDLINE]

Publication types, MeSH terms, Substances

Publication types

MeSH terms


Supplemental Content

Loading ...
Support Center