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J Neurobiol. 1998 Apr;35(1):65-76.

Molecular characterization of NOS in a mollusc: expression in a giant modulatory neuron.

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Sussex Centre for Neuroscience, School of Biological Sciences, University of Sussex, Brighton, UK.


Here we report on the molecular characterization of the first molluscan NOS in the CNS of the pond snail Lymnaea stagnalis. This Lymnaea NOS (Lym-nNOS) which is expressed preferentially in the CNS is most similar to mammalian neuronal NOS but contains tandem repeats of a seven amino acid motif not found in any other known NOS. We have localized Lym-nNOS to the serotonergic cerebral giant cells (CGCs) which modulate synaptic transmission within a neural network that generates feeding behavior. Our results suggest that the CGCs employ both NO and serotonin in the modulation of the central neural network underlying feeding.

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