Format

Send to

Choose Destination
Structure. 1998 Mar 15;6(3):255-8.

NO news is good news.

Author information

1
Department of Molecular Biology and Biochemistry, University of California, Irvine 92697-3900, USA. poulos@uci.edu

Abstract

The recent determination of the crystal structure of microsomal cytochrome P450 reductase, a diflavin protein that shuttles electrons from NADPH to the P450 heme, represents a significant advance towards the understanding of cytochromes P450. A similar advance was made in a related enzyme system, nitric oxide synthase (NOS). The crystal structure of the NOS heme domain reveals a very different architecture to that observed in P450s and offers significant insight into the production of nitric oxide, one of nature's most important regulatory molecules.

PMID:
9551547
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center